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Stress testingshould never be performed if the patient is having current chest pain; chest pain is areason to stop a stress test. Based on such study designs, investigators have averaged the concentrationsat each time point and derived the average AUCs in bone and plasma (naive averaging)[6–8]

Based on such study designs, investigators have averaged the concentrationsat each time point and derived the average AUCs in bone and plasma (naive averaging)[6–8].

However, despite the fact that ACT has the essential elements necessary toachieve the immunological eradication of the tumor, Tregs are still present and continue tointerfere with the positive outcomes of clinical trials utilizing this type of cancerimmunotherapy.

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