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The Bruceprotocol stress test includes heart rate and rating ofperceived exertion, which are taken every minuteand blood pressure every three minutes (Table 8.6).The test has been modified for sedentary and elderlypatients and can be cross-referenced with target heartrate by age (Figure 8.6). following exposure, micedevelop many of the same pathological signs, includingloss of the neurotransmitter dopamine and dopamineneurons in the substantia nigra pars compacta as well asbehavioral symptoms, such as reduced locomotion that areroutinely observed in patients with PD

following exposure, micedevelop many of the same pathological signs, includingloss of the neurotransmitter dopamine and dopamineneurons in the substantia nigra pars compacta as well asbehavioral symptoms, such as reduced locomotion that areroutinely observed in patients with PD.